Advances in Topical Therapies for Clinically Relevant and Prevalent Forms of Alopecia

December 2024 in “ Life ”

Aarushi K. Parikh, Isabella J. Tan, S. Wolfe, Bernard A. Cohen

minoxidil corticosteroids Janus kinase inhibitors androgenetic alopecia alopecia areata telogen effluvium scarring alopecias botanical extracts peptides Rogaine JAK inhibitors

TLDR Topical treatments like minoxidil and corticosteroids are effective for hair loss, with JAK inhibitors promising for alopecia areata.

The review discusses the effectiveness of topical therapies for various forms of alopecia, including androgenetic alopecia, alopecia areata, telogen effluvium, and scarring alopecias. It highlights treatments like minoxidil, corticosteroids, and Janus kinase inhibitors, noting their mechanisms, efficacy, and safety. Minoxidil and corticosteroids are effective across multiple alopecia types, while JAK inhibitors show promise for alopecia areata. The review emphasizes personalized treatment plans and identifies future research areas to improve outcomes for hair loss patients. Additionally, it explores novel treatments, including botanical extracts and peptides, and the role of patient-reported outcomes in evaluating treatment success.

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research Androgenic Alopecia Is Associated With Higher Dietary Inflammatory Index And Lower Antioxidant Index Scores

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Antioxidant-rich diets may reduce hair loss risk, while pro-inflammatory diets may increase it, especially in women.

research A Bibliometric Analysis of Alternative Drug Therapy Options in the Treatment of Androgenetic Alopecia

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Dutasteride is the most studied alternative drug for androgenetic alopecia, but more high-quality research is needed.

Patient-Reported Outcomes of Topical Finasteride/Minoxidil Treatment for Male Androgenetic Alopecia: A Retrospective Study Using Telemedical Data

research Patient-Reported Outcomes of Topical Finasteride/Minoxidil Treatment for Male Androgenetic Alopecia: A Retrospective Study Using Telemedical Data

May 2024 in “Journal of cosmetic dermatology”

Topical finasteride/minoxidil is effective but not better than oral finasteride for hair loss.

research Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction

November 2023 in “Foods”

Arabica coffee pulp extract may help prevent hair loss and promote hair growth.

Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

research Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

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Saw palmetto extract reduced hair loss and improved hair growth in people with hair thinning.

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57 citations , August 2023 in “American Journal of Clinical Dermatology”

JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.

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2 citations , June 2023 in “Indian journal of dermatology, venereology, and leprology”

Janus kinase inhibitors can regrow hair in alopecia areata but may cause side effects and hair loss may return if treatment stops.

research The Efficacy of Topical Prostaglandin Analogs for Hair Loss: A Systematic Review and Meta-Analysis

1 citations , March 2023 in “Frontiers in Medicine”

Topical prostaglandin analogs may help with hair growth but more research is needed.

research Role and Mechanisms of Phytochemicals in Hair Growth and Health

2 citations , January 2023 in “Pharmaceuticals”

Natural products and phytochemicals may help with hair regrowth, but more research is needed.

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research Comparative Evaluation of the Efficacy of Topical Tacrolimus 0.03% and Topical Calcipotriol 0.005% Mixed With Betamethasone Dipropionate Versus Topical Clobetasol 0.05% in Treatment of Alopecia Areata: A Clinical and Trichoscopic Study

1 citations , December 2022 in “Journal of cosmetic dermatology”

The combination of vitamin D analogues with potent steroids is a favorable treatment for alopecia areata with fewer side effects.

$Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment$

research Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

2 citations , April 2022 in “Clinical, cosmetic and investigational dermatology”

A new plant-based treatment was effective for hair regrowth in women with a specific type of hair loss that didn't respond to usual treatments.

research Minoxidil: A Comprehensive Review

16 citations , June 2021 in “Journal of Dermatological Treatment”

Minoxidil effectively treats hair loss, especially androgenetic alopecia, but needs more research for better understanding.

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40 citations , June 2021 in “Clinical, cosmetic and investigational dermatology”

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

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23 citations , February 2021 in “Dermatologic therapy”

Some treatments like pentoxifylline with topical corticosteroids might work for alopecia areata, but more research is needed to find the best one.

research Telogen Effluvium: A Review of the Literature

40 citations , May 2020 in “Cureus”

The conclusion is that treatments for Telogen Effluvium exist, but standard treatment guidelines are needed.

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

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10 citations , April 2020 in “Dermatology and therapy”

Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.

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8 citations , January 2020 in “Skin appendage disorders”

Saw palmetto supplements may modestly improve hair regrowth with few side effects, but more research is needed.

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Ketoconazole may help regrow hair and increase follicle size, but more research needed.

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56 citations , August 2019 in “Clinical, Cosmetic and Investigational Dermatology”

The document concludes that Telogen Effluvium is a hair loss disorder that can be assessed with the modified wash test and may be treated with clobetasol foam, with patient management being important.

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9 citations , June 2019 in “Archives of Dermatological Research”

Both topical calcipotriol and narrowband UVB improved alopecia, but combining them didn't enhance the effect on hair loss severity, despite higher vitamin D3 levels.

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45 citations , April 2019 in “International Immunology”

The study concluded that immune cells attacking hair follicles cause hair loss in alopecia, with genetics and environment also playing a role, and highlighted the potential of certain treatments.

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16 citations , January 2019 in “Skin appendage disorders”

Intralesional corticosteroids work best for mild alopecia areata, and DPCP works best for moderate to severe cases.

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21 citations , January 2017 in “Skin Pharmacology and Physiology”

Caffeine-based liquid 0.2% is as effective as minoxidil 5% for treating male hair loss.

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37 citations , August 2016 in “Clinical, Cosmetic and Investigational Dermatology”

The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.

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61 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hair usually grows back 1-3 months after treatment for anagen effluvium, and children with Loose Anagen Hair Syndrome often improve by adolescence.

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1 citations , January 2013 in “PubMed”

Adenosine led to higher patient satisfaction than minoxidil for hair loss treatment.