Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

    Heggar Venkataramana Sudeep, S Rashmi, Thomas V Jestin, Aleksander Richards, Kuluvar Gouthamchandra, Kodimule Shyamprasad
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    TLDR Saw palmetto extract reduced hair loss and improved hair growth in people with hair thinning.
    A 16-week study involving 80 subjects with mild-to-moderate Androgenetic Alopecia (AGA) found that both oral and topical applications of VISPO, a standardized saw palmetto extract, effectively reduced hair fall. The oral VISPO treatment group saw a 24.74% and 29% reduction in hair shedding after 8 and 16 weeks respectively, while the topical VISPO group saw a 12.08% and 22.19% reduction. Additionally, the oral VISPO group experienced a 5.17% increase in hair density and a significant increase in hair thickness, while the topical group saw a 7.61% increase in hair density after 16 weeks. The oral VISPO group also showed a significant reduction in serum Dihydrotestosterone (DHT) levels, suggesting that oral VISPO could inhibit 5α-reductase activity, reducing DHT accumulation. The study concluded that VISPO can be effectively used in functional and cosmetic formulations for hair loss treatment, but longer-term treatment may be required for full hair regrowth in AGA patients.
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      Saw palmetto + minoxidil + nizoral + dermaroller

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      in Journals / Progress Pictures  207 upvotes 1 month ago
      The user replaced finasteride with saw palmetto due to availability issues and experienced side effects, leading to adjustments in their regimen. They use saw palmetto, minoxidil, Nizoral, and a dermaroller, reporting reduced side effects and some benefits, with hair fall ranging from 5 to 20 hairs daily.

      community Saw palmetto and Pumpkin seed oil natural DHT blockers

      in Product 2 months ago
      Saw palmetto and pumpkin seed oil are generally considered ineffective for hair regrowth compared to finasteride and minoxidil. Users report that finasteride, minoxidil, and sometimes dutasteride are more reliable for maintaining and regrowing hair.

      community Which compounds in Saw Palmetto are actually beneficial?

      in Research/Science  2 upvotes 7 months ago
      Saw palmetto's fatty acids, particularly lauric and linoleic acids, inhibit enzymes linked to hair loss, while sterols like beta-sitosterol are less effective due to poor absorption. The conversation questions which specific compounds in saw palmetto contribute to its anti-androgenic effects.

      community (Topic) does saw palmetto actually work?

      in Chat  1 upvotes 8 months ago
      Saw palmetto can help reduce DHT levels and may work in combination with other supplements like beta sitosterol and pygume, but it's less effective than finasteride. Additional treatments like pumpkin seed extract, zinc, biotin, essential oils, scalp massages, and micro-needling can support hair health, but should not replace existing treatments like finasteride.

      community Saw Palmetto/Pumkin seed gives basically same results as Fin

      in Treatment 10 months ago
      A user reported that Procerin, containing Saw Palmetto and Pumpkin seed oil, provided similar hair thickening results as finasteride but with milder side effects. They experienced reduced libido and watery ejaculations but are adjusting the dose to minimize these effects.

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