Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

    Heggar Venkataramana Sudeep, S Rashmi, Thomas V Jestin … Kodimule Shyamprasad
    Studysummary This study found that both oral and topical formulations of VISPOTM, a saw palmetto oil, significantly reduced hair fall and increased hair density in subjects with androgenetic alopecia, with no serious adverse effects observed.
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    Research cited in this study 27

    1. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    2. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    3. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    4. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    5. Serenoa Repens Extracts Promote Hair Regeneration and Repair of Hair Loss in Mouse Models by Activating TGF-β and Mitochondrial Signaling Pathway PubMed · 2018
    6. Adverse Effects with Finasteride 5 mg/Day for Patterned Hair Loss in Premenopausal Women International Journal of Trichology · 2018
    7. A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors Medical Hypotheses · 2017
    8. A Novel Multi-Targeting Approach to Treating Hair Loss Using Standardized Nutraceuticals PubMed · 2017
    9. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    10. Androgenetic Alopecia: A Review Endocrine · 2017
    11. Interventions for Female Pattern Hair Loss JAMA Dermatology · 2017
    12. Efficacy of a Nutritional Supplement Standardized in Fatty Acids and Phytosterols on Hair Loss and Hair Health in Both Women and Men Journal of cosmetology & trichology · 2017
    13. Efficacy and Safety of a Food Supplement Containing L-Cystine, Serenoa Repens Extract, and Biotin for Hair Loss in Healthy Males and Females: A Prospective, Randomized, Double-Blinded, Controlled Clinical Trial Journal of cosmetology & trichology · 2017
    14. Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review PubMed · 2016
    15. Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract for 5α-Reductase Isoform II Inhibition Using a Cell-Free In Vitro Test System Research and reports in urology · 2016
    16. Frontal Fibrosing Alopecia Treatment Options Intractable & Rare Diseases Research · 2016
    17. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    18. Hair Growth: Focus on Herbal Therapeutic Agents Current Drug Discovery Technologies · 2015
    19. Treatment of Male Androgenetic Alopecia with Topical Products Containing Serenoa Repens Extract Australasian Journal of Dermatology · 2015
    20. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    21. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    22. Young Men's Coping with Androgenetic Alopecia: Acceptance Counts When Hair Gets Thinner Body Image · 2011
    23. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    24. Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid, and Saw Palmetto Extract Evidence-based Complementary and Alternative Medicine · 2009
    25. Hair Evaluation Methods: Merits and Demerits International Journal of Trichology · 2009
    26. Standardizing the 60-Second Hair Count Archives of Dermatology · 2008
    27. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998

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