TLDR Certain skin cells near the base of hair muscles may help renew and stabilize skin, possibly affecting skin disorder understanding.
In a 2016 study, researchers examined the distribution of epidermal stem cells in nonglabrous skin, focusing on their proximity to the distal end of the arrector pili muscle (APM). They discovered that a specific group of basal keratinocytes expressing stem cell markers such as K15, MCSP, and α6 integrin are situated in a niche at the lowest part of the rete ridges near the APM attachment site. The study, which used skin specimens from six adult mice, supported the idea that these stem cells are organized hierarchically rather than randomly, potentially contributing to skin renewal and stability. The findings also suggested that the APM might be involved in maintaining the stem cell niche, which could have implications for understanding skin disorders like nonmelanoma skin cancer.
106 citations,
March 2014 in “BioEssays” We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.
35 citations,
March 2014 in “British Journal of Dermatology” Hair loss in male pattern baldness involves muscle degeneration and increased scalp fat.
22 citations,
January 2012 in “International Journal of Trichology” Miniaturized hairs stay connected to muscle in alopecia areata, allowing possible regrowth, but not in androgenetic alopecia.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
5 citations,
January 2016 in “Stem Cells International” Certain skin cells near the base of hair muscles may help renew and stabilize skin, possibly affecting skin disorder understanding.
8 citations,
March 2009 in “Differentiation” Adult vibrissa follicle stem cells can regenerate hair follicles, glands, and skin.
45 citations,
May 2003 in “Journal of Cell Science” α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.
