TLDR Adult vibrissa follicle stem cells can regenerate hair follicles, glands, and skin.
In this study, researchers successfully cultured and detached intact bulge keratinocyte sheets from rat vibrissa follicles using thermo-responsive culture dishes, avoiding conventional enzymatic digestion. When these sheets were recombined with adult dermal papilla (DP) and sole skin dermis in vivo, they observed the regeneration of epidermis, sebaceous gland-like structures, and hair bulb formation within 3 weeks. However, no structures formed when cloned bulge keratinocytes were used, suggesting the presence of monoclonal stem cells in the bulge region. This provided direct evidence that adult bulge keratinocytes are multipotent and can respond to adult DP signals to induce hair follicle formation.
291 citations,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
11 citations,
October 2001 in “Tissue engineering” Cultured epithelium can form hair follicles when combined with dermal papillae.
72 citations,
June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
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1010 citations,
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68 citations,
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232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
321 citations,
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25 citations,
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Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.
21 citations,
October 2009 in “Biochemical Engineering Journal” Stem cell therapy is a promising approach for hair regrowth despite potential side effects.
