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GlossaryKeratin 17 (KRT17)

protein crucial for skin, hair, and nail structure

Keratin 17 (K17) is a type of protein found in the skin, hair follicles, and nails, playing a crucial role in their structural integrity and resilience. It is also involved in cellular processes like growth and repair, and its abnormal expression is linked to certain skin disorders and cancers.

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research Promoter Methylation Changes in KRT17: A Novel Epigenetic Marker for Wool Production in Angora Rabbit

2 citations, May 2022 in “International journal of molecular sciences”

Changes in KRT17 gene activity linked to wool production in Angora rabbits.

research KRT17 Promotes Endometrial Cancer Cell Migration and Angiogenesis by Regulating HIF-1α/VEGF Pathway

January 2023 in “European journal of gynaecological oncology”

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations, October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations, December 2015 in “Journal of Investigative Dermatology”

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations, August 2020 in “Genes”

Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

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