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GlossaryKeratin 17 (KRT17)

protein crucial for skin, hair, and nail structure

Keratin 17 (K17) is a type of protein found in the skin, hair follicles, and nails, playing a crucial role in their structural integrity and resilience. It is also involved in cellular processes like growth and repair, and its abnormal expression is linked to certain skin disorders and cancers.

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research Promoter Methylation Changes in KRT17: A Novel Epigenetic Marker for Wool Production in Angora Rabbit

2 citations , May 2022 in “International journal of molecular sciences”

Changes in KRT17 gene activity linked to wool production in Angora rabbits.

KRT17 Promotes Endometrial Cancer Cell Migration and Angiogenesis by Regulating HIF-1α/VEGF Pathway

research KRT17 Promotes Endometrial Cancer Cell Migration and Angiogenesis by Regulating HIF-1α/VEGF Pathway

January 2023 in “European journal of gynaecological oncology”

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations , October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research Comparative Anatomy of Mouse and Human Nail Units

55 citations , February 2013 in “The Anatomical Record”

Mouse nails are similar to human nails, making them useful for studying nail diseases.

research Homozygous Dominant Missense Mutation in Keratin 17 Leads to Alopecia in Addition to Severe Pachyonychia Congenita

22 citations , February 2012 in “Journal of Investigative Dermatology”

A specific gene mutation causes severe skin and nail issues and hair loss.

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