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    Bald Thigh Syndrome in Sighthounds: Revisiting the Cause of a Well-Known Disease

    February 2019 in “ PloS one ”
    Magdalena A. T. Brunner, Silvia Rüfenacht, Anina Bauer … Monika Welle
    Studysummary This study found that structural defects in the hair shafts of sighthounds with bald thigh syndrome are related to a downregulation of genes and proteins essential for hair shaft formation.
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    Research cited in this study 40

    1. A Second KRT71 Allele in Curly Coated Dogs Animal Genetics · 2018
    2. Development of Hair Fibers Advances in experimental medicine and biology · 2018
    3. Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins Advances in experimental medicine and biology · 2018
    4. Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X PLOS ONE · 2017
    5. A Curated Catalog of Canine and Equine Keratin Genes PLoS ONE · 2017
    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    7. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    8. Novel KRT83 and KRT86 Mutations Associated with Monilethrix Experimental Dermatology · 2015
    9. Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments BMC genomics · 2014
    10. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    11. Loss-Of-Function Mutations In HOXC13 Cause Pure Hair And Nail Ectodermal Dysplasia The American Journal of Human Genetics · 2012
    12. Keratin 71 Mutations: From Water Dogs to Woolly Hair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    13. A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012
    14. Canine Noninflammatory Alopecia: A Comprehensive Evaluation of Common and Distinguishing Histological Characteristics Veterinary Dermatology · 2012
    15. A Case of Monilethrix Caused by Novel Compound Heterozygous Mutations in the Desmoglein 4 (DSG4) Gene British Journal of Dermatology · 2011
    16. The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71 Mammalian genome · 2010
    17. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    18. Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene Journal of Veterinary Medical Science · 2010
    19. Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation Differentiation · 2009
    20. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    21. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    22. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    23. Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007
    24. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    25. Human Hair Keratin-Associated Proteins ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    26. Hair Shaft Abnormalities: Clues to Diagnosis and Treatment Dermatology · 2005
    27. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    28. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    29. Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency Journal of Investigative Dermatology · 2003
    30. K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2003
    31. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    32. Characterization of the Cysteine-Rich Calcium-Binding S100A3 Protein from Human Hair Cuticles Biochemical and biophysical research communications · 2002
    33. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    34. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    35. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    36. A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001
    37. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    38. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    39. Ultrastructural Localization of S100A3, a Cysteine-Rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-Freezing Immunocytochemistry Journal of Histochemistry & Cytochemistry · 1999
    40. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998