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Research

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research Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

December 2025 in “FEBS Open Bio”

In this study, fibroblasts from long-term skin biopsy cultures retained their ability to reprogram into induced pluripotent stem cells after 16 months, despite undergoing transcriptional changes and decreased proliferation rates over successive generations.

research Skin self-photography for dysplastic nevus monitoring is associated with a decrease in the number of biopsies at follow-up: A retrospective analytical study

5 citations , September 2015 in “Journal of The American Academy of Dermatology”

This letter highlights that the effectiveness of skin self-photography for melanoma detection has not been evaluated, although it could be a cost-effective option for patients without access to professional skin photography.

research Retrospective study: the presence ofMalasseziain feline skin biopsies. A clinicopathological study

66 citations , February 2002 in “Veterinary dermatology”

This study suggests that the presence of Malassezia yeast in biopsy specimens from cats with multifocal or generalized skin lesions indicates the need for a thorough assessment for internal neoplasia.

research Increased acetylcholine levels in skin biopsies of patients with atopic dermatitis

96 citations , March 2003 in “Life Sciences”

This study found that acetylcholine levels in the superficial skin of atopic dermatitis patients were significantly higher compared to healthy volunteers, suggesting a potential role in skin cell regulation.

research Research Techniques Made Simple: Optical Clearing and Three-Dimensional Volumetric Imaging of Skin Biopsies

2 citations , June 2020 in “Journal of Investigative Dermatology”

This article reviews the steps and methods involved in preparing skin tissues for three-dimensional volumetric imaging, highlighting its potential to provide detailed insights into skin structure not possible with traditional 2D histology, but reports no new findings.

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Community Join

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Ultrasound can show you if your hair will ever grow back

in Research/Science 41 upvotes 5 months ago

Ultrasound imaging can non-invasively detect active and inactive hair follicles, inflammation, and fibrosis, potentially reducing unnecessary biopsies. It may help assess hair growth potential and diagnose scalp issues, but some users believe in trying treatments regardless of ultrasound results.

community Losing Hair on Dutasteride? You might have LPP

96 upvotes 1 year ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community Crazy growth after adding ostrich oil + microneedling in 2 months. (already on treatment previously)

65 upvotes 1 month ago

The user experienced significant hair growth after adding ostrich oil and weekly microneedling to their existing treatment of topical dutasteride and minoxidil. They believe the combination of ostrich oil and microneedling contributed to the results, although some users suggest the increased microneedling frequency might be the main factor.

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Learn

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learn Melatonin

Can melatonin cause side effects on the skin or hair? No study links melatonin to hair loss; reports are anecdotal. Some users report scalp dryness or irritation from topical products, and a safety review lists mainly mild side effects such as sleepiness and headache.

learn Follistatin

Can follistatin be applied to the skin, and does any form of it treat hair loss? No study shows that follistatin applied to the skin works, and no form of follistatin is an approved or proven hair-loss treatment. Follistatin injections, "research peptides" and gene therapies sold outside regulated trials are unapproved and of unknown safety.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid improved hydration of facial skin in trials. It has not been tested on the scalp.

learn Osteopontin

What does osteopontin do in skin healing and inflammation? Osteopontin takes part in wound repair in mouse skin; its role in human scalp healing and inflammation has not been studied.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Providers say SMP pigment can be matched to many skin tones and hair colors; claims that it works on all of them are marketing.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin