A Curated Catalog of Canine and Equine Keratin Genes

    August 2017 in “ PLoS ONE ”
    Pierre Balmer, Anina Bauer, Shashikant Pujar, Kelly M. McGarvey, Monika Welle, Arnaud Galichet, Eliane J. Müller, Kim D. Pruitt, Tosso Leeb, Vidhya Jagannathan
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    TLDR 61 functional keratin genes were identified in dogs and horses, leading to updated gene annotations.
    The study focused on the annotation of keratin genes in dogs and horses, highlighting the challenges due to high similarity between keratin paralogs and species-specific differences. Researchers compared gene predictions from NCBI and Ensembl with RNA-seq data from adult skin and hair follicle tissues of five dogs and two horses. They identified 61 putatively functional keratin genes in both species. The findings led to updates in the annotation and nomenclature of several keratin genes, which were reviewed by the RefSeq group at NCBI and are now available in the NCBI Gene database.
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