A Curated Catalog of Canine and Equine Keratin Genes

August 2017 in “ PLoS ONE ”

Pierre Balmer, Anina Bauer, Shashikant Pujar, Kelly M. McGarvey, Monika Welle, Arnaud Galichet, Eliane J. Müller, Kim D. Pruitt, Tosso Leeb, Vidhya Jagannathan

keratin genes hair follicle RNA-seq skin

Studysummary This study identified and updated the annotation of 61 keratin genes in dogs and horses, improving the genome annotation in these species through RNA-seq data comparison. Our plain-language summary of this paper — not a Tressless recommendation.

The study focused on the annotation of keratin genes in dogs and horses, highlighting the challenges due to high similarity between keratin paralogs and species-specific differences. Researchers compared gene predictions from NCBI and Ensembl with RNA-seq data from adult skin and hair follicle tissues of five dogs and two horses. They identified 61 putatively functional keratin genes in both species. The findings led to updates in the annotation and nomenclature of several keratin genes, which were reviewed by the RefSeq group at NCBI and are now available in the NCBI Gene database.

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Research cited in this study

8 / 8 results

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research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.