Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly

    July 2015 in “ PLoS ONE ”
    David J. Bray, Tiffany R. Walsh, Massimo G. Noro, Rebecca Notman
    Studysummary This study presents the first detailed 3D models of the complete K1/K10 keratin dimer and identifies structural features and interactions that may inform understanding of keratin filament assembly.
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    Research cited in this study 6

    1. The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia Current opinion in cell biology · 2012
    2. Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein Biomacromolecules · 2012
    3. Molecular Modeling of Hair Keratin/Peptide Complex: Using MM-PBSA Calculations to Describe Experimental Binding Results Proteins · 2012
    4. Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins Journal of Cell Science · 2011
    5. Keratin Gene Mutations in Disorders of Human Skin and Its Appendages Archives of Biochemistry and Biophysics · 2010
    6. Three-Dimensional Modelling of Interchain Sequence Similarities and Differences in the Coiled-Coil Segments of Keratin Intermediate Filament Heterodimers Highlight Features Important in Assembly Journal of Structural Biology · 2007