Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein

    September 2012 in “ Biomacromolecules ”
    C.K. Chou, Markus J. Buehler
    Studysummary This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.
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    Research cited in this study 9

    1. Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins Journal of Cell Science · 2011
    2. In Situ Tensile Deformation Characterization of Human Hair with Atomic Force Microscopy Acta materialia · 2007
    3. Three-Dimensional Modelling of Interchain Sequence Similarities and Differences in the Coiled-Coil Segments of Keratin Intermediate Filament Heterodimers Highlight Features Important in Assembly Journal of Structural Biology · 2007
    4. Structural Changes in Trichocyte Intermediate Filaments During Transition from Reduced to Oxidized Form Journal of Structural Biology · 2007
    5. Multiscale Modelling of Human Hair Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · 2004
    6. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments ˜The œjournal of cell biology/˜The œJournal of cell biology · 2000
    7. Sequences and Differential Expression of Three Novel Human Type-II Hair Keratins Differentiation · 1997
    8. Human Hair Keratins Journal of Investigative Dermatology · 1993
    9. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002