Transcriptomics Analysis Reveals Molecular Alterations Underpinning Spaceflight Dermatology

The study examines the molecular changes in skin health due to spaceflight, using data from astronauts and mice. It identifies significant gene expression changes, such as DNA damage, mitochondrial dysregulation, and alterations in skin barrier function, which pose risks to skin health during space missions. The research includes data from 6 astronauts' blood samples, 10 astronauts' hair follicles, and skin biopsies from the Inspiration4 mission, revealing changes in immune response, muscle morphology, and fibrosis. Key findings include the downregulation of collagen biosynthesis pathways and genes like CASP14 and FLG, suggesting stress-induced suppression of collagen production. The study highlights the potential for developing countermeasures to mitigate spaceflight-associated skin damage, crucial for long-term missions to the Moon and Mars.