Transcriptomics Analysis Reveals Molecular Alterations Underpinning Spaceflight Dermatology

This study investigates the molecular changes in skin health due to spaceflight by analyzing transcriptomic data from murine models, biochemical profiles of 50 NASA astronauts, and samples from JAXA astronauts and the Inspiration4 mission. The research identifies key biological changes, such as DNA damage, repair issues, and mitochondrial dysregulation, as contributors to skin health risks during spaceflight. A machine learning model highlights gene pairings linked to spaceflight responses, revealing alterations in genes related to skin barrier function and collagen formation. Despite these changes, organisms show a strong ability to readapt post-flight. The findings aim to inform future research on countermeasures for spaceflight-induced skin damage.