Estrogens and Aging Skin

April 2013 in “ Dermato-endocrinology ”

M. Julie Thornton

estrogen estrogen deficiency menopause skin aging collagen wound healing estrogen replacement SERMs phytoestrogens anagen phase skin pigmentation non-melanoma skin cancers antioxidant properties oxidative stress selective estrogen receptor modulators plant estrogens

Studysummary This review discusses the effects of estrogen on skin aging and highlights potential therapies, but reports no new clinical findings.

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Research cited in this study

8 / 8 results

research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

27 citations , October 2011 in “British Journal of Dermatology”

This study builds on previous findings by associating female pattern hair loss with gene polymorphisms related to oestrogen activity, suggesting oestrogen's role in the condition.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , April 2009 in “British Journal of Dermatology”

In this study, genetic variation in the CYP19A1 gene, particularly the common rs4646 C allele, was associated with an increased risk of female pattern hair loss, especially in women under 40.

research Differing Responses of Human Follicular and Nonfollicular Scalp Cells in an In Vitro Wound Healing Assay: Effects of Estrogen on Vascular Endothelial Growth Factor Secretion

30 citations , March 2008 in “Wound Repair and Regeneration”

This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.

research Effect of Estrogens on Skin Aging and the Potential Role of SERMs

120 citations , October 2007 in “Clinical Interventions in Aging”

This review discusses the effects of estrogens on skin aging and highlights the potential benefits of estrogen replacement therapy and selective estrogen receptor modulators for improving skin health in postmenopausal women, but reports no new clinical findings.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.

research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

This study found that dexamethasone significantly reduced ERα mRNA levels and increased aromatase mRNA and activity in cultured human hair follicle dermal papilla cells, suggesting a glucocorticoid-dependent mechanism for estradiol action.

research Estrogen Functions in Skin and Skin Appendages

68 citations , June 2005 in “Expert Opinion on Therapeutic Targets”

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

research The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.