Skin Aging

May 2007 in “ Menopause International ”

Jean Calleja-Agius, Y Muscat-Baron, Mark Brincat

postmenopausal estrogen deficiency collagen loss skin changes estrogen replacement skin collagen content dermal thickness elasticity wound healing TGF-ß secretion hormone replacement therapy estrogen deficiency collagen estrogen therapy collagen content skin thickness skin elasticity TGF-beta HRT

TLDR After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.

The 2007 review highlights that skin ageing is influenced by factors such as postmenopausal estrogen deficiency, which leads to significant collagen loss and skin changes. Postmenopausal women can experience up to a 30% reduction in skin collagen within the first five years after menopause, with a continued decline thereafter. Estrogen replacement has been shown to improve skin collagen content, dermal thickness, and elasticity, and may also enhance wound healing by inducing TGF-ß secretion. However, the effects on wound healing are not fully understood, and there are varying impacts on other skin components and psychosexual function. Despite the potential benefits of estrogen for skin health post-menopause, the review emphasizes the need for large-scale clinical trials to establish clear guidelines for the use of hormone replacement therapy in the prevention of skin ageing.

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