Effect of Estrogens on Skin Aging and the Potential Role of Selective Estrogen Receptor Modulators

The 2007 document examines the role of estrogens and selective estrogen receptor modulators (SERMs) in combating skin aging. It highlights that hormone replacement therapy (HRT) has beneficial effects on skin, such as improving collagen content and elasticity, but is not recommended solely for this purpose due to potential risks. Topical estrogens have been found to enhance skin moisture and firmness and reduce wrinkles, with a study involving 54 women showing significant improvements in skin thickness and fine wrinkles after using a conjugated estrogen cream for 24 weeks. However, concerns about systemic absorption suggest that estradiol creams might be safer. The document also notes that while phytoestrogens and SERMs like raloxifene could benefit skin aging, their side effects require further study. The document concludes that HRT and topical estrogens are effective for skin aging, but the safety and efficacy of alternatives like phytoestrogens and SERMs need more investigation, and any treatment should be managed by a dermatologist with endocrinological expertise.