Differing Responses of Human Follicular and Nonfollicular Scalp Cells in an In Vitro Wound Healing Assay: Effects of Estrogen on Vascular Endothelial Growth Factor Secretion

    March 2008 in “ Wound Repair and Regeneration ”
    Susan C. Stevenson, Anthony H. Taylor, Aisha Meskiri, David T. Sharpe, M. Julie Thornton
    TLDR Estrogen affects scalp cell types differently, enhancing some wound healing processes.
    This study examined the effects of 17β-estradiol on VEGF secretion and wound healing in human scalp cells, specifically dermal fibroblasts (DF), dermal papilla (DP), and dermal sheath (DS) cells, from 7 female patients. It found that estrogen enhanced wound healing by promoting cell migration and DNA synthesis, particularly in DF cells, and modulated VEGF secretion differently across cell types. Mechanical wounding increased collagen and VEGF secretion in DF and DS cells but not in DP cells. Estrogen increased VEGF in DP cells and decreased it in DS cells, indicating distinct roles for these cells in hair follicle angiogenesis and the hair cycle. The presence of estrogen receptors suggested that estrogen could influence these processes, highlighting its potential role in improving wound healing and hair cycle regulation.
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