Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

August 2009 in “ Differentiation ”

Hisham Bazzi, Shadmehr Demehri, Christopher S. Potter, Alison G. Barber, Alexander Awgulewitsch, Raphael Kopan, Angela M. Christiano

Desmoglein 4 DSG4 hair shaft cortex transcription factors hair keratin keratin-associated protein KAP HOXC13 LEF1 FOXN1 Notch pathway hair follicle mutations beaded hair monilethrix hair cortex keratin Notch

TLDR Desmoglein 4 is controlled by specific proteins that affect hair growth.

The study investigated the regulation of Desmoglein 4 (DSG4), a protein essential for hair shaft differentiation, by various transcription factors. It was found that HOXC13, LEF1, and FOXN1 repressed DSG4 transcription, while Notch signaling indirectly regulated its expression. The research highlighted a complex regulatory network involving both repressors and activators that control DSG4 expression, contributing to our understanding of hair shaft differentiation and potential targets for addressing hair disorders.

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Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

Research cited in this study

research Smad4-Dependent Desmoglein-4 Expression Contributes to Hair Follicle Integrity

research Localized Autosomal Recessive Hypotrichosis Due to a Frameshift Mutation in the Desmoglein 4 Gene Exhibits Extensive Phenotypic Variability Within a Pakistani Family

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research An Autosomal Recessive Form of Monilethrix Is Caused by Mutations in DSG4: Clinical Overlap with Localized Autosomal Recessive Hypotrichosis

research Mutations in the Desmoglein 4 Gene Underlie Localized Autosomal Recessive Hypotrichosis with Monilethrix Hairs and Congenital Scalp Erosions

research Proteome Analysis of Human Hair Shaft

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research Learning From Nudity: Lessons From The Nude Phenotype

research A Missense Mutation in the Cadherin Interaction Site of the Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis

research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats

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