Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

    August 2009 in “ Differentiation ”
    Hisham Bazzi, Shadmehr Demehri, Christopher S. Potter … Angela M. Christiano
    Studysummary This study found that transcription factors HOXC13, LEF1, and FOXN1 repress DSG4 transcription, with the Notch pathway possibly involved in maintaining DSG4 expression in hair follicles.
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    Research cited in this study 18

    1. Smad4-Dependent Desmoglein-4 Expression Contributes to Hair Follicle Integrity Developmental Biology · 2008
    2. Localized Autosomal Recessive Hypotrichosis Due to a Frameshift Mutation in the Desmoglein 4 Gene Exhibits Extensive Phenotypic Variability Within a Pakistani Family ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    3. Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    4. An Autosomal Recessive Form of Monilethrix Is Caused by Mutations in DSG4: Clinical Overlap with Localized Autosomal Recessive Hypotrichosis Journal of Investigative Dermatology · 2006
    5. Mutations in the Desmoglein 4 Gene Underlie Localized Autosomal Recessive Hypotrichosis with Monilethrix Hairs and Congenital Scalp Erosions Journal of Investigative Dermatology · 2006
    6. Proteome Analysis of Human Hair Shaft Molecular & Cellular Proteomics · 2006
    7. Mutations in the Desmoglein 4 Gene Are Associated with Monilethrix-Like Congenital Hypotrichosis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    8. Learning From Nudity: Lessons From The Nude Phenotype Experimental Dermatology · 2005
    9. A Missense Mutation in the Cadherin Interaction Site of the Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis Journal of Investigative Dermatology · 2005
    10. Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats Journal of Investigative Dermatology Symposium Proceedings · 2005
    11. Keratins of the Human Hair Follicle International review of cytology · 2005
    12. Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat Differentiation · 2004
    13. Krtap16: Characterization of a New Hair Keratin-Associated Protein Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 Journal of Biological Chemistry · 2004
    14. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    15. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    16. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    17. Lanceolate Hair-J (LahJ): A Mouse Model for Human Hair Disorders Experimental dermatology · 2000
    18. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998

    Related research 3

    1. Keratins of the Human Hair Follicle International review of cytology · 2005
    2. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    3. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002