TLDR Desmoglein 4 is controlled by specific proteins that affect hair growth.
The study investigated the transcriptional regulation of Desmoglein 4 (DSG4), a key desmosomal cadherin in the hair shaft cortex, by transcription factors known to regulate hair keratin and keratin-associated protein (KAP) expression. The researchers found that transcription factors HOXC13, LEF1, and FOXN1 repressed DSG4 transcription. Additionally, they provided both in vitro and in vivo evidence suggesting that the Notch pathway is involved in the activation and/or maintenance of DSG4 expression in the hair follicle. Mutations in hair keratins or DSG4 were linked to beaded hair phenotypes, such as monilethrix.
Cited in this study
7 / 7 results
28 citations
,
October 2008 in “Developmental Biology” Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.
25 citations
,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific gene mutation causes varying hair loss severity in a Pakistani family.
65 citations
,
September 2006 in “Journal of biological chemistry/The Journal of biological chemistry” The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
74 citations
,
June 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” Mutations in the DSG4 gene can cause a rare hair disorder similar to monilethrix.
86 citations
,
October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
28 citations
,
October 2004 in “Differentiation” A gene deletion causes the "hairless" trait in Iffa Credo rats.
37 citations
,
June 2000 in “Experimental dermatology” The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.
