Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

August 2009 in “ Differentiation ”

Hisham Bazzi, Shadmehr Demehri, Christopher S. Potter, Alison G. Barber, Alexander Awgulewitsch, Raphael Kopan, Angela M. Christiano

Desmoglein 4 DSG4 hair shaft cortex transcription factors hair keratin keratin-associated protein KAP HOXC13 LEF1 FOXN1 Notch pathway hair follicle mutations beaded hair monilethrix hair cortex keratin Notch

TLDR Desmoglein 4 is controlled by specific proteins that affect hair growth.

The study investigated the regulation of Desmoglein 4 (DSG4), a protein essential for hair shaft differentiation, by various transcription factors. It was found that HOXC13, LEF1, and FOXN1 repressed DSG4 transcription, while Notch signaling indirectly regulated its expression. The research highlighted a complex regulatory network involving both repressors and activators that control DSG4 expression, contributing to our understanding of hair shaft differentiation and potential targets for addressing hair disorders.

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