1H NMR-Based Lipidomics of Rodent Fur: Species-Specific Lipid Profiles and SCD1 Inhibitor-Related Dermal Toxicity

July 2014 in “ Journal of Lipid Research ”

Purnima Khandelwal, Steven A. Stryker, Hannguang J. Chao, Nelly Araníbar, R. Michael Lawrence, Malavi T. Madireddi, Wenjun Zhao, Luping Chen, Michael D. Reily

1H NMR-based lipidomics lipid profiles SCD1 inhibitors dermal toxicity sebaceous excretions sebum lipids sebaceous gland atrophy sebum sterol ester NMR lipidomics skin toxicity skin oils skin lipids skin gland atrophy skin sterol ester

TLDR SCD1 inhibitors can cause skin issues in rodents.

The study utilized 1H NMR-based lipidomics to analyze species-specific lipid profiles in rodent fur and assess the impact of Stearoyl-CoA Desaturase 1 (SCD1) inhibitors on dermal toxicity. It found significant reductions in various lipids in rats and hamsters treated with the SCD1 inhibitor, with mice showing dermal pathology such as alopecia and sebaceous gland atrophy. The research demonstrated that NMR is a powerful, noninvasive tool for characterizing skin lipids, allowing for serial sampling and reducing the need for euthanizing animals. The method also highlighted the importance of considering age, gender, and body region in dermatological studies and identified cholesta-7,24-dien-3β-ol esters as a key biomarker.

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1H NMR-Based Lipidomics of Rodent Fur: Species-Specific Lipid Profiles and SCD1 Inhibitor-Related Dermal Toxicity

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