Flavonoids and Saponins: What Have We Got or Missed?

    December 2022 in “ Phytomedicine ”
    Xuanbin Wang, Yan Ma, Qihe Xu, Alexander N. Shikov, Olga N. Pozharitskaya, E. V. Flisyuk, Meifeng Liu, Hongliang Li, Liliana Vargas-Murga, Pierre Duez
    Image of study
    TLDR More high-quality research is needed to recommend flavonoids and saponins for clinical use.
    The review paper "Flavonoids and saponins: What have we got or missed?" discusses the potential therapeutic effects of flavonoids and saponins, bioactive compounds found in various plants. Flavonoids have been linked to conditions like chronic venous insufficiency, diabetes, and male pattern hair loss, while saponins may impact conditions like venous oedema and erectile dysfunction. However, the paper highlights that in vivo and clinical data are often insufficient to support clinical recommendations, with only 10 meta-analyses and systematic reviews (involving 290 interventional and observational studies), and 36 clinical studies on flavonoids and saponins. The authors call for more research to fill these gaps and better understand the true value of these compounds. The document also discusses the potential overrated importance of antioxidants, as antioxidative therapies have not been as effective as expected. The anticancer mechanisms of flavonoids and saponins are complex and involve multiple targets. The document concludes that further high-quality studies are needed before recommending a clinical use for these natural products.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 17 results

      community New Study - Flavonoids More Effective Than Finasteride?

      in Research/Science  148 upvotes 2 years ago
      A recent publication suggests that the flavonoids eriocitrin and silymarin may be more effective than finasteride in binding to the enzyme responsible for hair loss. People in the conversation are skeptical about the effectiveness and safety of these flavonoids until tested on humans, and some discuss their personal experiences with other treatments.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Natural Remedies: Polyphenols and Hair Loss

       21 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2448 upvotes 4 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

    Similar Research

    5 / 1000+ results