Effects of Flavonoid Derivatives on Human Microvascular Endothelial Cells

March 2016 in “ Natural Product Research ”

Eleonora Bassino, Susanna Antoniotti, F Gasparri, Luca Munaron

flavonoid derivatives visnadin hesperidin baicalin human microvascular endothelial cells HMEC hair growth minoxidil VEGFR-2 phosphorylation proangiogenic signaling tubulogenesis hair follicle growth hair growth disorders VSD HSP BC MXD VEGFR-2

Studysummary This study found that baicalin promotes human microvascular endothelial cell proliferation, while visnadin and minoxidil enhance tubulogenesis, with hesperidin uniquely increasing VEGFR-2 phosphorylation compared to other compounds tested. Our plain-language summary of this paper — not a Tressless recommendation.

The study from 2016 examined the impact of three flavonoid derivatives—visnadin (VSD), hesperidin (HSP), and baicalin (BC)—on human microvascular endothelial cells (HMEC) in the context of hair growth, comparing their effects to minoxidil (MXD), a known hair loss treatment. BC was found to increase HMEC proliferation, VSD and MXD improved tubulogenesis, and HSP was the only compound to enhance VEGFR-2 phosphorylation, a key factor in proangiogenic signaling. Despite this, HSP did not promote tubule formation. The findings suggest that these flavonoids may have selective effects on vascular-mediated hair follicle growth, indicating a potential for treating hair growth disorders. The exact number of subjects or cells tested was not mentioned in the summary.

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