Effects of Flavonoid Derivatives on Human Microvascular Endothelial Cells

    March 2016 in “ Natural Product Research ”
    Eleonora Bassino, Susanna Antoniotti, F Gasparri, Luca Munaron
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    TLDR Some flavonoids may help with hair growth by affecting blood vessel function in hair follicles.
    The study from 2016 examined the impact of three flavonoid derivatives—visnadin (VSD), hesperidin (HSP), and baicalin (BC)—on human microvascular endothelial cells (HMEC) in the context of hair growth, comparing their effects to minoxidil (MXD), a known hair loss treatment. BC was found to increase HMEC proliferation, VSD and MXD improved tubulogenesis, and HSP was the only compound to enhance VEGFR-2 phosphorylation, a key factor in proangiogenic signaling. Despite this, HSP did not promote tubule formation. The findings suggest that these flavonoids may have selective effects on vascular-mediated hair follicle growth, indicating a potential for treating hair growth disorders. The exact number of subjects or cells tested was not mentioned in the summary.
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