LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium Pyrenaicum Burm. F.: A Good Gift from the Natural Treasure

    July 2021 in “ International Journal of Molecular Sciences ”
    Łukasz Świątek, Elwira Sieniawska, Kouadio Ibrahime Sinan, Magdalena Maciejewska‐Turska, Anastazja Boguszewska, Małgorzata Polz‐Dacewicz, İsmail Şenkardeş, Gökalp Özmen Güler, Nabeelah Bibi Sadeer, Mohamad Fawzi Mahomoodally, Gökhan Zengin
    TLDR Geranium pyrenaicum extracts show potential for cancer, antiviral, and enzyme inhibition treatments.
    The study analyzed the chemical composition and bioactive properties of four extracts from Geranium pyrenaicum using LC-ESI-QTOF-MS/MS. The aqueous extract, rich in phenolic content, showed the highest antioxidant activity and selectivity towards cancer cell lines, particularly FaDu cells. The methanolic extract demonstrated significant antiviral activity against HSV-1 and inhibited tyrosinase and α-glucosidase activities. Ethyl acetate extracts inhibited cholinesterase and α-amylase enzymes. A total of 56 compounds, including ellagitannins and gallic acid derivatives, were identified, highlighting the plant's potential for developing innovative phyto-pharmaceuticals. Further research was recommended to identify the most active compounds and confirm their efficacy.
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