This study developed a three-dimensional model for studying hair follicle development, showing that immortalized dermal papilla cells retain certain differentiation activities and can induce tubule formation in vitro.
28 citations
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March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
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March 2016 in “Natural Product Research” This study found that baicalin promotes human microvascular endothelial cell proliferation, while visnadin and minoxidil enhance tubulogenesis, with hesperidin uniquely increasing VEGFR-2 phosphorylation compared to other compounds tested.
This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.
August 2023 in “Scientific reports” In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.