Determination of Solute Diffusion Properties in Artificial Sebum

May 2019 in “ Journal of pharmaceutical sciences ”

Sen Yang, Lingyi Li, Minsheng Lu, Tao Chen, Lujia Han, Guoping Lian

artificial sebum diffusion cell sebum film sebum-water partition coefficients diffusion coefficients stratum corneum lipids hair follicle transdermal permeation skin oils skin barrier skin absorption

TLDR Diffusion in artificial sebum is mainly influenced by molecular size and is much faster than in skin lipids.

The study measured the diffusion properties of 17 chemical compounds across artificial sebum using a diffusion cell. It found two distinct behaviors in diffusion flux: steady-state and non-steady-state. Mathematical models were developed to fit the data, considering factors like sebum film thickness and boundary layer resistance. The sebum-water partition coefficients derived from the models matched well with previous experimental data. The diffusion coefficients in artificial sebum were primarily influenced by molecular size and were about ten times higher than those in stratum corneum lipids. Changes in pH affected the diffusion flux of ionic chemicals by altering their partition coefficients, suggesting that hair follicles significantly contribute to overall skin permeation.

View this study on jpharmsci.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study

research Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study

35 citations, June 2017 in “Pharmaceutical research”

Researchers developed a model that shows hair follicles increase skin absorption of caffeine by 20%.

research Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals

39 citations, November 2016 in “Pharmaceutics”

The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.

research The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs

12 citations, March 2012 in “ATLA. Alternatives to laboratory animals”

Hair follicles significantly affect the skin absorption of some drugs.

research Human Hair Follicle: Reservoir Function and Selective Targeting

97 citations, September 2011 in “British Journal of Dermatology”

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

research Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

94 citations, May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.

research Targeting to the Hair Follicles: Current Status and Potential

142 citations, January 2010 in “Journal of dermatological science”

Hair follicles are promising targets for delivering drugs effectively.

research Diffusion Properties of Model Compounds in Artificial Sebum

29 citations, May 2007 in “International journal of pharmaceutics”

Different compounds move through artificial sebum at different rates, which can help choose the best ones for targeting hair follicles.

research Transfollicular Drug Delivery: Is It a Reality?

141 citations, November 2005 in “International journal of pharmaceutics”

Hair follicles may soon be used more for targeted and systemic drug delivery.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations, January 2004 in “Journal of Investigative Dermatology”

Hair follicle size and distribution vary significantly across different body sites.

Similar Research

5 / 1000+ results

research Latanoprost-Loaded Nanotransfersomes Designed For Scalp Administration Enhance Keratinocytes Proliferation

December 2022 in “Molecular Pharmaceutics”

Latanoprost-loaded nanotransfersomes could help treat hair loss by promoting hair growth.

research Ex Vivo Permeation Parameters and Skin Deposition of Melatonin-Loaded Microemulsion for Treatment of Alopecia

4 citations, May 2022 in “Future Journal of Pharmaceutical Sciences”

Melatonin-loaded microemulsion could be a promising treatment for hair loss.

research Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice

2 citations, December 2021 in “Pharmaceutics”

Finasteride-loaded proniosomes effectively promote hair growth in mice.

research Transfollicular Drug Delivery: Current Perspectives

10 citations, April 2016 in “Research and reports in transdermal drug delivery”

Transfollicular drug delivery is promising but needs more research to improve and understand it better.

Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

research Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

14 citations, June 2014 in “Journal of Pharmaceutical Sciences”

Formulation P-08-016 better targets hair follicles for baldness treatment.