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research Investigation of drug partition property in artificial sebum

33 citations , June 2007 in “International Journal of Pharmaceutics”

This study found that the sebum partition coefficient (K(sebum)) for some drugs differs from the stratum corneum partition coefficient (K(sc)), indicating its importance for targeted drug delivery into hair and sebaceous follicles.

research Determination of Solute Diffusion Properties in Artificial Sebum

6 citations , May 2019 in “Journal of pharmaceutical sciences”

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

research Comparison of artificial sebum with human and hamster sebum samples

49 citations , September 2008 in “International journal of pharmaceutics”

This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.

research A Composite Model for the Transport of Hydrophilic and Lipophilic Compounds Across the Skin: Steady-State Behavior

32 citations , September 2018 in “Journal of pharmaceutical sciences”

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

research Diffusion properties of model compounds in artificial sebum

29 citations , May 2007 in “International journal of pharmaceutics”

This study found that drug transport through artificial sebum varies depending on the compound, suggesting that sebum-targeted delivery can be optimized by selecting compounds based on their distinct transport profiles in sebum versus skin.

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community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community Oral: 1.2mg Fin, 3mg Min, 2.5mg Biotin, 11 mg Vit B5, 2.5mg Vit B6, 100mg Vit C. Topical serum: Batana, Rosemary, Castor oils, Rice water, and more Biotin

in I'm Starting Treatment 5 months ago

A user started a hair loss treatment 6 weeks ago using oral finasteride, minoxidil, biotin, vitamins B5, B6, and C, along with a topical serum containing batana, rosemary, castor oils, rice water, and more biotin. They are hoping to see progress by June-July.

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