Latanoprost-Loaded Nanotransfersomes Designed For Scalp Administration Enhance Keratinocytes Proliferation

December 2022 in “ Molecular Pharmaceutics ”

Eloy Pena-Rodríguez, Laura García-Vega, Maria Lajarin Reinares, Marçal Pastor-Anglada, Sandra Pérez-Torras, Francisco Fernandez-Campos

latanoprost nanotransfersomes keratinocyte proliferation alopecia MAPK pathway PI3K pathway hair growth drug delivery skin penetration hair loss hair disorders

TLDR Latanoprost-loaded nanotransfersomes could help treat hair loss by promoting hair growth.

The study developed latanoprost-loaded nanotransfersomes for scalp administration to enhance keratinocyte proliferation, aiming to treat hair disorders like alopecia. These nanotransfersomes, characterized by their small size (<100 nm) and stability, significantly improved drug delivery and skin penetration. Encapsulated latanoprost notably increased keratinocyte proliferation via the MAPK and PI3K pathways, unlike free latanoprost. The findings suggest that latanoprost-loaded nanotransfersomes could be a promising approach for promoting hair growth and treating alopecia.

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