Latanoprost-Loaded Nanotransfersomes Designed For Scalp Administration Enhance Keratinocytes Proliferation

December 2022 in “ Molecular Pharmaceutics ”

Eloy Pena-Rodríguez, Laura García-Vega, Maria Lajarin Reinares, Marçal Pastor-Anglada, Sandra Pérez-Torras, Francisco Fernandez-Campos

latanoprost nanotransfersomes keratinocyte proliferation alopecia MAPK pathway PI3K pathway hair growth drug delivery skin penetration hair loss hair disorders

TLDR Latanoprost-loaded nanotransfersomes could help treat hair loss by promoting hair growth.

The study developed latanoprost-loaded nanotransfersomes for scalp administration to enhance keratinocyte proliferation, aiming to treat hair disorders like alopecia. These nanotransfersomes, characterized by their small size (<100 nm) and stability, significantly improved drug delivery and skin penetration. Encapsulated latanoprost notably increased keratinocyte proliferation via the MAPK and PI3K pathways, unlike free latanoprost. The findings suggest that latanoprost-loaded nanotransfersomes could be a promising approach for promoting hair growth and treating alopecia.

View this study on pubs.acs.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia

9 citations, February 2022 in “European Journal of Pharmaceutics and Biopharmaceutics”

A new treatment for hair loss uses tiny lipid carriers to deliver a mix of minoxidil and latanoprost directly to hair follicles, promoting hair growth and being well tolerated by the skin.

Utilization of Nanotechnology and Experimental Design in Development and Optimization of Aloe Vera Gel Loaded with Finasteride-Garlic Oil-Nanotransfersomes

research Utilization of Nanotechnology and Experimental Design in Development and Optimization of Aloe Vera Gel Loaded with Finasteride-Garlic Oil-Nanotransfersomes

1 citations, January 2022 in “Journal of Drug Delivery Science and Technology”

A gel made with finasteride, garlic oil, and Aloe vera using nanotechnology can potentially treat hair loss more effectively.

research Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls

8 citations, May 2021 in “Bioengineering & translational medicine”

Hair growth environment recreated with challenges; stem cells make successful skin organoids.

research Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

12 citations, May 2021 in “Clinical Interventions in Aging”

Men with androgenetic alopecia have oilier and less hydrated scalps, especially in sensitive areas.

research Stem and Progenitor Cells in Sebaceous Gland Development, Homeostasis, and Pathologies

19 citations, March 2021 in “Experimental dermatology”

Stem cells are key for the growth, upkeep, and repair of sebaceous glands and for understanding skin disorders.

research Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach

24 citations, July 2018 in “Drug Design Development and Therapy”

NTF gel improves finasteride delivery for hair loss treatment, reducing side effects.

research Transdermal Permeation of Drugs in Various Animal Species

149 citations, September 2017 in “Pharmaceutics”

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro

32 citations, January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

research Prostaglandin Analogs for Hair Growth: Great Expectations

20 citations, January 2003 in “Dermatology online journal”

Prostaglandin analogs like Latanoprost might help grow hair on the scalp and body.

Similar Research

5 / 389 results

research Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field

August 2024 in “Stem Cell Research & Therapy”

New regenerative therapies show promise for treating hair loss.

Hypertrichosis and Increased Pigmentation of Eyelashes and Adjacent Hair in the Region of the Ipsilateral Eyelids of Patients Treated with Unilateral Topical Latanoprost

research Hypertrichosis and Increased Pigmentation of Eyelashes and Adjacent Hair in the Region of the Ipsilateral Eyelids of Patients Treated with Unilateral Topical Latanoprost

216 citations, October 1997 in “American Journal of Ophthalmology”

Using the eye pressure medication latanoprost can cause excessive hair growth and darker eyelashes on the treated eye.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations, August 2011 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations, March 2009 in “Journal of The American Academy of Dermatology”

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

research Latanoprost in the Treatment of Eyelash Alopecia in Alopecia Areata Universalis

50 citations, December 2009 in “Journal of The European Academy of Dermatology and Venereology”

Latanoprost can effectively treat eyelash hair loss, with 45% of patients showing hair regrowth and no reported side effects.