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Glossary Transdermal Permeation

process where substances pass through skin into bloodstream

Transdermal permeation refers to the process by which substances pass through the skin and enter the bloodstream. This method is often used in medical treatments, such as with transdermal patches, to deliver drugs directly into the body without the need for injections or oral medications. The skin's outer layer acts as a barrier, so formulations must be designed to effectively penetrate this layer to achieve therapeutic effects.

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research Transdermal Permeation of Drugs in Various Animal Species

149 citations , September 2017 in “Pharmaceutics”

This review compares animal and human skin characteristics in in vitro permeation studies but reports no new results, highlighting variations and the need for better model correlations.

research Mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes

105 citations , April 2017 in “International Journal of Nanomedicine”

In this study, ethosomes were found to improve the skin penetration of a model lipophilic drug more effectively than liposomes or hydroethanolic solutions, suggesting a unique mechanism involving the breakdown of vesicles in the skin.

research Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo

61 citations , March 2006 in “Colloids and surfaces. B, Biointerfaces”

In this study, lecithin/n-propanol/isopropyl myristate/water/tetracaine hydrochloride microemulsion was found to be a safe carrier for transdermal drug delivery in animal models, with analgesic effects on Wistar rats.

research Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study

35 citations , June 2017 in “Pharmaceutical research”

This study presented a new two-dimensional model that successfully predicts transdermal permeation of caffeine, highlighting the significant role of the follicular pathway in increasing systemic bioavailability.

research Transdermal film-loaded finasteride microplates to enhance drug skin permeation: Two-step optimization study

30 citations , March 2016 in “European Journal of Pharmaceutical Sciences”

This study found that using drug microplates in transdermal finasteride films enhances aqueous solubility and skin permeation compared to films with pure finasteride.

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community Progressive insomnia (treatment-resistant) due to Finasteride

8 upvotes 4 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community 2 years fin only 1mg/daily + 4 months of gradually introducing Dut 0.5mg/daily

1706 upvotes 1 year ago

A user experienced significant hair regrowth using finasteride 1 mg daily for two years and gradually introduced dutasteride 0.5 mg daily over four months. They reported no side effects and plan to switch fully to dutasteride due to its cost-effectiveness and potential effectiveness.

community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

15 upvotes 4 years ago

The conversation discusses hair regrowth using dissolvable microneedles loaded with rapamycin and epigallocatechin gallate nanoparticles. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

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