Transdermal Permeation of Tetracaine Hydrochloride by Lecithin Microemulsion: In Vivo

    March 2006 in “ Colloids and surfaces. B, Biointerfaces ”
    Mohammad Changez, Jagdish Chander, Amit Kumar Dinda
    TLDR Lecithin microemulsion safely delivers tetracaine hydrochloride through the skin.
    The study demonstrated that using lecithin-based microemulsions significantly increased the local analgesic response of tetracaine hydrochloride when applied transdermally. Both water-in-oil and oil-in-water microemulsions were effective, with the analgesic response depending on the microemulsion composition. The lecithin/n-propanol/isopropyl myristate/water microemulsion was found to be a safe carrier for transdermal drug delivery, as confirmed by histopathological, irritancy, and biochemical tests on mice.
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