TLDR Microemulsions could improve skin drug delivery but face challenges like complex creation and potential toxicity.
Microemulsions, composed of an oil phase, a surfactant, a co-surfactant, and an aqueous phase, are a promising drug delivery system, particularly for cutaneous applications. Their small droplet size (10-100 nm) allows for efficient drug solubilization and enhanced bioavailability. They can deliver both hydrophilic and hydrophobic drugs, improving skin permeation and drug stability. However, challenges include the complexity of their formulation, potential toxicity of surfactants and co-surfactants, and stability issues affected by environmental factors. Examples of their use include treatments for antimicrobial, anti-inflammatory, fungicidal, and alopecia applications. Future research will focus on optimizing microemulsion formulations and exploring new therapeutic applications.
1 citations,
December 2022 in “Pharmaceutics” Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.
1 citations,
January 2022 in “Journal of Drug Delivery Science and Technology” The optimized microemulsion with cinnamon oil effectively delivers finasteride through the skin without damaging hair.
61 citations,
March 2006 in “Colloids and surfaces. B, Biointerfaces” Lecithin microemulsion safely delivers tetracaine hydrochloride through the skin.
72 citations,
December 2012 in “Expert Opinion on Drug Delivery” Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.
67 citations,
January 2022 in “Theranostics” Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.
15 citations,
October 2012 in “InTech eBooks” Niosomes are a promising and effective way to deliver drugs through the skin.
33 citations,
July 2021 in “Clinical, Cosmetic and Investigational Dermatology” Nanocarrier technology in cosmetics improves ingredient delivery and effectiveness while reducing side effects.
3 citations,
October 2014 in “Pharmaceutical Development and Technology” The study found a way to improve a skin-applied minoxidil formula using a specific design method.
