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GlossaryFranz diffusion cells

laboratory devices measuring substance diffusion through barriers

Franz diffusion cells are laboratory devices used to study the rate at which substances, such as drugs or cosmetic ingredients, pass through a barrier, typically skin or a synthetic membrane. They consist of two chambers separated by the barrier: one chamber holds the test substance, while the other contains a fluid that collects the diffused substance, allowing researchers to measure how quickly and effectively the substance penetrates the barrier.

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Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

research Influence of Application Time and Formulation Reapplication on the Delivery of Minoxidil through Hairless Mouse Skin as Measured in Franz Diffusion Cells

5 citations , January 1994 in “Skin Pharmacology and Physiology”

Minoxidil absorption in skin is slowed by cleansing, depends on how long it stays on the skin, and is not much affected by reapplication.

research Determination of Solute Diffusion Properties in Artificial Sebum

6 citations , May 2019 in “Journal of pharmaceutical sciences”

Diffusion in artificial sebum is mainly influenced by molecular size and is much faster than in skin lipids.

research Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data

82 citations , May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.

research The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs

12 citations , March 2012 in “ATLA. Alternatives to laboratory animals”

Hair follicles significantly affect the skin absorption of some drugs.

research Heat Enhanced Follicular Delivery of Isotretinoin to the Skin

8 citations , June 2019 in “Pharmaceutical research”

Applying heat with certain chemicals can greatly improve how well isotretinoin gets into the skin through hair follicles.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 76 upvotes 1 year ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community PP405 Identity Research

in Research 292 upvotes 4 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community First post: Baby Hair Regrowing on temples at 39

in Update 14 upvotes 3 months ago

A 39-year-old experienced hair regrowth on his temples after switching from finasteride to topical RU58841 combined with 5% minoxidil. He also underwent stem cell treatment and noticed improvements, attributing the regrowth mainly to the change in treatment.

community The Real Reason For Hair Loss?

in Research/Science 2 weeks ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community He used Dutasteride for 20 years. Interview

in Treatment 113 upvotes 1 year ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

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