Ex Vivo Permeation Parameters and Skin Deposition of Melatonin-Loaded Microemulsion for Treatment of Alopecia

    May 2022 in “ Future Journal of Pharmaceutical Sciences ”
    Asmaa A. Elshall, Amira M. Ghoneim, Heidi M. Abdel-Mageed, Rihab Osman, Dalia S. Shaker
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    TLDR Melatonin-loaded microemulsion could be a promising treatment for hair loss.
    The document discusses a study on the development and evaluation of a melatonin-loaded microemulsion (MEL ME) for treating androgenic alopecia. The MEL ME was formulated using coconut oil, Tween 80, and PEG 400, and was characterized for its size, uniformity, and stability. An ex vivo permeation study through rat skin showed that MEL ME had low steady-state skin flux and high stratum corneum deposition, indicating a controlled release manner. The study concluded that MEL ME could be a promising candidate for further permeation and in vivo studies for androgenic alopecia treatment.
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