Boosting Hair Growth Through Follicular Delivery of Melatonin Through Lecithin-Enhanced Pickering Emulsion Stabilized by Chitosan-Dextran Nanoparticles in Testosterone Induced Androgenic Alopecia Rat Model

    April 2023 in “ International Journal of Pharmaceutics ”
    Asmaa A. Elshall, Amira M. Ghoneim, Nehad M. Abd-elmonsif, Rihab Osman, Dalia S. Shaker
    TLDR Melatonin in a special emulsion can help treat hair loss more effectively.
    In this study, melatonin (MEL) was encapsulated in lecithin-enhanced Pickering emulsions (PE) stabilized by chitosan-dextran sulfate nanoparticles (CS-DS NPs) and compared with MEL-loaded microemulsions (ME) for their effectiveness in treating androgenetic alopecia (AGA). The PE formulation provided significant photoprotection, retaining MEL levels within the desired range, while 50% of MEL in ME degraded after 180 minutes of UV exposure. This enhanced photoprotection was attributed to the polymeric nanoparticles surrounding the PE droplets. The study suggests that PE formulations could be a promising approach for improving the stability and efficacy of MEL in AGA treatment.
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      community Thoughts of this sub on Melatonin?

      in Research/Science  3 upvotes 1 month ago
      Melatonin, gingko biloba, and biotin are effective for treating hair loss with good tolerability. Alternatives like dutasteride, minoxidil, and other peptides are also discussed.

      community Melatonin emerging as new treatment for androgenic alopecia?

      in Update  38 upvotes 3 months ago
      Melatonin is being considered as a potential treatment for androgenic alopecia, with some users discussing its effects and combining it with other treatments like minoxidil and finasteride. Concerns about melatonin's impact on hormones and side effects from other treatments like ketoconazole were also discussed.

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 9 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 11 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

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      in Treatment  6 upvotes 1 year ago
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