In Vitro and In Vivo Models for the Development of Hair Growth Materials by Regulating the β-Catenin Signaling Pathways

February 2024 in “ Journal of medicinal food ”

Min Jeong Woo, Jiwon Choi, Ha Yeong Kang, Sehyeon Jang, Min Jeong Kim, S. Y. Kim, Sun‐Sig Byun, Sung Keun Jung

β-catenin tegatrabetan human hair follicle dermal papilla cells HFDPCs GSK-3β Akt cyclin D1 G2/M phase arrest keratin 14 Ki67 beta-catenin TG hair follicle cells GSK-3 beta protein kinase B cell cycle arrest keratin

TLDR The research found a way to develop hair growth materials by targeting a specific signaling pathway.

This study developed a model for hair growth material development by regulating the β-catenin signaling pathway. Using 100 nM tegatrabetan (TG), a β-catenin inhibitor, researchers observed decreased proliferation and increased apoptosis in human hair follicle dermal papilla cells (HFDPCs) over 72 hours. TG also induced G2/M cell cycle arrest and suppressed hair growth in C57BL/6 mice by inhibiting the expression of cyclin D1, β-catenin, keratin 14, and Ki67. These findings suggest that TG-induced inhibition of hair growth can serve as a promising model for creating new materials to enhance β-catenin-mediated hair growth.

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