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Flavonoids in Safflower Extract Reduce Cisplatin-Induced Damage to Human Follicle Dermal Papilla Cells by Inhibiting DNA Damage and Rad17/Chk1/Cdc25C Signaling

research Flavonoids in Safflower Extract Reduce Cisplatin-Induced Damage to Human Follicle Dermal Papilla Cells by Inhibiting DNA Damage and Rad17/Chk1/Cdc25C Signaling

January 2023 in “Biocell”

Safflower extract helps protect hair follicle cells from damage caused by chemotherapy.

research In Vitro and In Vivo Models for the Development of Hair Growth Materials by Regulating the β-Catenin Signaling Pathways

February 2024 in “Journal of medicinal food”

The research found a way to develop hair growth materials by targeting a specific signaling pathway.

research Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy

32 citations , August 2019 in “Nature Communications”

Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.

research Semecarpus Anacardium Linn. Leaf Extract Exhibits Activities Against Breast Cancer And Prolongs The Survival Of Tumor-Bearing Mice

July 2021 in “Research Square (Research Square)”

Semecarpus anacardium leaf extract fights breast cancer and extends survival in mice.

research 5-Fluorouracil Induces Hair Loss by Inhibiting Beta-Catenin Signaling and Angiogenesis

February 2025 in “Chemico-Biological Interactions”

5-Fluorouracil causes hair loss by blocking signals needed for hair growth.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 3 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community 10 months on dutasteride. Lost about half of my hair density. Losing 150-250 hairsevery day

in Finasteride/Dutasteride 70 upvotes 1 year ago

User experienced significant hair loss after adding dutasteride to their finasteride and minoxidil regimen. They plan to revert to finasteride only due to lack of improvement.