The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells
May 2020
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Research Square (Research Square)
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corticotropin releasing factor CRF human dermal papilla cells DPCs hair follicles hair growth hair loss catagen transition cell cycle arrest G2/M phase reactive oxygen species ROS anagen-related cytokines proopiomelanocortin POMC adrenocorticotropic hormone ACTH cortisol hypothalamic–pituitary–adrenal axis HPA axis stress hormone hair shedding hair growth phase stress conditions
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary In this study, stress hormone CRF was found to inhibit hair growth, suggesting that the HPA axis is functional in human dermal papilla cells and contributes to hair loss under stress conditions.
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