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GlossaryCorticotropin-Releasing Hormone (CRF)

peptide hormone that triggers stress response via ACTH release

Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

research Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

38 citations , April 2018 in “Psychopharmacology/Psychopharmacologia”

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

research CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice

29 citations , February 2011 in “PloS one”

Astressin-B can reverse and prevent hair loss in stressed mice.

research A Possible Solution for Hair Loss by Inhibiting Corticotropin-Releasing Factor Receptor from Traditional Chinese Medicine

4 citations , September 2013 in “Journal of biomolecular structure and dynamics/Journal of biomolecular structure & dynamics”

Caribine from traditional Chinese medicine may help treat hair loss.

research Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Factor-Induced Cellular Senescence in Human Hair Follicular Cells

April 2023 in “Journal of Investigative Dermatology”

Ganoderma lucidum extract can potentially reduce stress-induced hair loss by slowing down premature hair aging and removing harmful substances.

research Effects of 1% Minoxidil Sulfate Injected Subcutaneously on Alopecia in CRF-OE Mice

December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)”

Minoxidil sulfate significantly improved hair growth in mice.

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community How does hair loss and recovery work?

in Chat 12 upvotes 1 year ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community PP405 - A True Breakthrough or Another Disappointment?

in Research/Science 33 upvotes 4 months ago

PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

community Federal Grant Cuts have impacted PP405 related research

in Technology 458 upvotes 2 months ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.