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GlossaryCorticotropin-Releasing Hormone (CRF)

peptide hormone that triggers stress response via ACTH release

Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

research Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

38 citations, April 2018 in “Psychopharmacology/Psychopharmacologia”

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

research CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice

29 citations, February 2011 in “PloS one”

Astressin-B can reverse and prevent hair loss in stressed mice.

research A Possible Solution for Hair Loss by Inhibiting Corticotropin-Releasing Factor Receptor from Traditional Chinese Medicine

4 citations, September 2013 in “Journal of biomolecular structure and dynamics/Journal of biomolecular structure & dynamics”

Caribine from traditional Chinese medicine may help treat hair loss.

research Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Factor-Induced Cellular Senescence in Human Hair Follicular Cells

April 2023 in “Journal of Investigative Dermatology”

Ganoderma lucidum extract can potentially reduce stress-induced hair loss by slowing down premature hair aging and removing harmful substances.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations, June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

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community How does hair loss and recovery work?

in Chat 12 upvotes 2 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.