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Glossary Protein Kinase B

enzyme involved in cell growth, metabolism, and survival

Protein Kinase B (PKB), also known as Akt, is a crucial enzyme in the body that plays a significant role in various cellular processes, including metabolism, cell proliferation, and survival. It is activated by signals from growth factors and other extracellular stimuli, and its dysregulation is often associated with diseases such as cancer and diabetes.

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research Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos

7 citations , September 2019 in “Journal of Cellular Physiology”

In this study, Akt2 and the oncogenic protein Tcl1 were found to be essential for early blastomere proliferation and embryo development in preimplantation mouse embryos.

research The biphasic regulatory effect of diphencyprone on mouse hair growth and its relation to protein kinase C isoforms

March 1998 in “Journal of dermatological science”

Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.

Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

This study found that AtT-20 pituitary cells with higher cAMP-dependent kinase activity had larger calcium currents and significantly increased beta-endorphin release compared to cells with lower kinase activity.

research Bisindolylmaleimide Protein-Kinase-C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures

11 citations , January 1997 in “Skin Pharmacology and Physiology”

This study found that bisindolylmaleimide PKC inhibitors increased DNA synthesis in mouse hair follicles, suggesting that PKC may inhibit hair follicle proliferation.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

June 2023 in “Frontiers in Medicine”

This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.

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community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

community Better Than Minoxidil? Topical Sodium Valproate

50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Creatine is the opposite of minoxidil !

324 upvotes 11 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

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learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Stem Cell Factor

learn Epidermal Growth Factor

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