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GlossaryMAPK pathway inhibitors

drugs that block cell growth and survival signaling pathways

MAPK pathway inhibitors are drugs that block the Mitogen-Activated Protein Kinase (MAPK) pathway, a critical signaling pathway that regulates cell growth, division, and survival. By inhibiting this pathway, these drugs can help treat conditions like cancer and certain types of alopecia, where abnormal cell growth or survival is a problem.

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research Targeted Therapy in Melanoma

21 citations, February 2013 in “Clinics in Dermatology”

New treatments for advanced skin cancer are improving patient outcomes, but drug resistance and finding the right treatment combinations are still big challenges.

research The Pathogenesis and Treatment Progress of Androgenic Alopecia

January 2024 in “Journal of Biosciences and Medicines”

Future treatments for androgenic alopecia may focus on reactivating hair follicle stem cells and improving drug delivery.

research Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails

179 citations, October 2018 in “American Journal of Clinical Dermatology”

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Clinical Management of Cutaneous Adverse Events in Patients on Targeted Anticancer Therapies and Immunotherapies: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

research Clinical Management of Cutaneous Adverse Events in Patients on Targeted Anticancer Therapies and Immunotherapies: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

26 citations, October 2018 in “Clinical & Translational Oncology”

Spanish experts provided guidelines for treating skin side effects in cancer patients on new therapies, stressing early action and teamwork.

research Dermatologic Adverse Events from Cancer Treatments

2 citations, October 2018 in “Springer eBooks”

Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.