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    Glossary MAPK pathway inhibitors

    drugs that block cell growth and survival signaling pathways

    MAPK pathway inhibitors are drugs that block the Mitogen-Activated Protein Kinase (MAPK) pathway, a critical signaling pathway that regulates cell growth, division, and survival. By inhibiting this pathway, these drugs can help treat conditions like cancer and certain types of alopecia, where abnormal cell growth or survival is a problem.

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    1. Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway Drug Design Development and Therapy · 2025
    2. 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells Molecules · 2025
    3. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    4. The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms Journal of Dermatological Science · 2018 · 21 citations
    5. Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima Processes · 2020 · 15 citations
    6. Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells Biomedical dermatology · 2018 · 3 citations
    7. 691 Topical curcumin promotes induction of the murine hair cycle 2016 · 3 citations
    8. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations
    9. Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep BMC genomics · 2018 · 17 citations
    10. 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways 2022
    11. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias Medical Science Monitor · 2018 · 10 citations
    12. Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy? Experimental Dermatology · 2006
    13. NF-κB in biology and targeted therapy: new insights and translational implications Signal transduction and targeted therapy · 2024 · 1 citations
    14. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    15. Betulinic acid exerts anti‐hepatitis C virus activity via the suppression of NF‐κB‐ and MAPK‐ERK1/2‐mediated COX‐2 expression British Journal of Pharmacology · 2015 · 44 citations
    16. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    17. Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts Current Issues in Molecular Biology · 2025 · 1 citations
    18. Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons Chemosphere · 2017 · 10 citations
    19. PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats BMC Veterinary Research · 2025 · 1 citations
    20. Anticancer Effects of Cepharanthine: an Updated Minireview Journal of Cancer · 2026
    21. Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis Human genomics · 2022 · 8 citations
    22. Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin International Journal of Molecular Sciences · 2022 · 7 citations
    23. Biological therapy in the treatment of melanoma Journal of Mind and Medical Sciences · 2018 · 3 citations
    24. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    25. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020 · 25 citations
    26. 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction Neurobiology of Disease · 2018 · 26 citations
    27. Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment Journal of Ethnopharmacology · 2024
    28. Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia Biology · 2024
    29. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    30. Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( <i>Capra hircus</i> ) Royal Society Open Science · 2018 · 11 citations