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    Glossary Protein Kinase C inhibitors

    blockers that prevent enzyme activity affecting cell growth and differentiation

    Protein Kinase C (PKC) inhibitors are substances that block the activity of Protein Kinase C, an enzyme involved in various cellular processes such as cell growth, differentiation, and apoptosis. By inhibiting PKC, these blockers can potentially be used to treat conditions like cancer, cardiovascular diseases, and certain skin disorders, including alopecia, where abnormal PKC activity is implicated.

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    1. Bisindolylmaleimide Protein-Kinase-C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures Skin Pharmacology and Physiology · 1997 · 11 citations
    2. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    3. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000 · 32 citations
    4. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    5. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    6. Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease Innovation in aging · 2020
    7. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    8. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    9. Protein Kinase C as a Therapeutic Target Clinical Cancer Research · 2006 · 87 citations
    10. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
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    1. Procyanidin Plant polyphenol found in apples and grape seeds
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