Caffeic Acid Skin Absorption: Delivery of Microparticles to Hair Follicles

    September 2019 in “ Saudi pharmaceutical journal ”
    Lia Carolina Oliveira dos Santos, Caroline Magnani Spagnol, Antonio José Guillot, Ana Melero, Marcos Antônio Corrêa
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    TLDR Microparticles help caffeic acid stay longer in hair follicles for better treatment of folliculitis.
    The study investigated the delivery of caffeic acid (CA) to hair follicles using O/W-emulsions containing CA-loaded controlled-release microparticles to treat folliculitis. Traditional and differential tape stripping techniques showed that microparticles provided a more homogeneous distribution and higher retention of CA within the stratum corneum and hair follicles compared to free CA. This method allowed for a continuous release of CA, potentially enabling effective treatment with a single dose until the microparticles were naturally removed or depleted.
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