Caffeic Acid Skin Absorption: Delivery of Microparticles to Hair Follicles

The study investigated the delivery of caffeic acid (CA) to hair follicles using O/W-emulsions containing CA-loaded controlled-release microparticles to treat folliculitis. Traditional and differential tape stripping techniques showed that microparticles provided a more homogeneous distribution and higher retention of CA within the stratum corneum and hair follicles compared to free CA. This method allowed for a continuous release of CA, potentially enabling effective treatment with a single dose until the microparticles were naturally removed or depleted.