Getting Under the Skin: What Is the Potential of the Transfollicular Route in Drug Delivery?

The document explored the potential of the transfollicular route for drug delivery, emphasizing its advantages such as noninvasiveness, sustained drug delivery, and reduced systemic toxicity. Hair follicles were identified as significant pathways for drug penetration due to their large contact area and storage volume. The use of nanoparticles was highlighted for improving drug delivery to hair follicles, allowing for targeted and sustained release. Clinical applications included treatments for hair diseases, acne, and transcutaneous immunization. Despite its promise, the transfollicular route required further exploration and optimization to meet safety and usability standards. The study also reviewed various nanotechnology-based delivery systems and discussed their safety profile and regulatory considerations.