Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

    June 2021 in “ Molecules ”
    Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Adriana Alonso Novais, Vinícius Augusto Simão, Virna Margarita Martín Giménez, Walter Manucha, Débora Aparecida Pires de Campos Zuccari, Rüssel J. Reiter
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    TLDR Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.
    The document reviews the use of melatonin-loaded nanocarriers (NCs) to improve the delivery and therapeutic efficacy of melatonin. Melatonin has poor water solubility and a short half-life, which limits its bioavailability when taken orally. By incorporating melatonin into nanocarriers like lipid-based, polymeric, and non-ionic surfactant-based vesicles, its stability is enhanced, and controlled release is achieved, leading to better solubility and potentially improved clinical outcomes. The review also covers specific applications of these NCs, such as nanofibrous mats for sleep disorders, chitosan-based nanoparticles for wound healing and glioblastoma treatment, and synthetic polymeric nanoparticles like PCL and PLA for targeted drug delivery in glioblastoma treatment and bone engraftment. The document concludes that melatonin-loaded NCs are more effective than free melatonin and calls for further research to optimize these systems for clinical use.
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