Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
June 2021
in “
Molecules
”
melatonin nanocarriers lipid-based vesicles polymeric vesicles non-ionic surfactant-based vesicles nanofibrous mats chitosan-based nanoparticles synthetic polymeric nanoparticles PCL PLA NCs lipid vesicles polymer vesicles surfactant vesicles nanofibers chitosan nanoparticles polymer nanoparticles polycaprolactone polylactic acid
TLDR Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.
The document reviews the use of melatonin-loaded nanocarriers (NCs) to improve the delivery and therapeutic efficacy of melatonin. Melatonin has poor water solubility and a short half-life, which limits its bioavailability when taken orally. By incorporating melatonin into nanocarriers like lipid-based, polymeric, and non-ionic surfactant-based vesicles, its stability is enhanced, and controlled release is achieved, leading to better solubility and potentially improved clinical outcomes. The review also covers specific applications of these NCs, such as nanofibrous mats for sleep disorders, chitosan-based nanoparticles for wound healing and glioblastoma treatment, and synthetic polymeric nanoparticles like PCL and PLA for targeted drug delivery in glioblastoma treatment and bone engraftment. The document concludes that melatonin-loaded NCs are more effective than free melatonin and calls for further research to optimize these systems for clinical use.
