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Neural Crest Stem Cells

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Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

research Human Epidermal Neural Crest Stem Cells (hEPI-NCSC): Characterization and Directed Differentiation into Osteocytes and Melanocytes

91 citations, March 2011 in “Stem Cell Reviews and Reports”

Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.

research CDK9 Kinase Activation in Association with AFF1-SEC Initiates Epidermal Progenitor Differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: An Approach to Pathogenesis by Evidence from Translational Biology

112 citations, January 2013 in “Experimental dermatology”

Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations, May 2020 in “Frontiers in immunology”

Hidradenitis suppurativa might be a type of autoinflammatory skin disease.

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community Source for Pyrilutamide has disappeared

in Treatment 21 upvotes 2 years ago

Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

community From Nov. 2022 to today. 2.5 oral min/ .5 oral duta/ Nizoral every once and a while

in Progress Pictures 133 upvotes 2 years ago

A user's progress with hair growth using oral minoxidil, oral dutasteride and Nizoral shampoo every once in a while. Replies indicate that the user has seen good results from this treatment, including thickening and darkening of their hair.

community Pyrilutamide update, comparing with ru58841

in Research/Science 25 upvotes 2 years ago

Treatments for hair loss, including Minoxidil, finasteride, and RU58841. The post discusses the potential benefits of Pyrilutamide compared to RU58841 in terms of strength and longevity.

community Ru-58841 or KX-826 (Pyrilutamide)?

in Treatment 12 upvotes 2 years ago

Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

community My Pyrilutamide Experience Photos

in Update 598 upvotes 2 years ago

A user's experience with Pyrilutamide, a topical treatment for hair loss that they used in combination with other treatments such as Minoxidil and Finasteride. The user experienced impressive results in a short amount of time.

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