November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.
91 citations
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March 2011 in “Stem Cell Reviews and Reports” Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.
14 citations
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May 2008 in “Journal of Visualized Experiments” Mouse Epidermal Neural Crest Stem Cells (EPI-NCSC) were multipotent stem cells located in the bulge of hair follicles, capable of differentiating into various cell types such as neurons, nerve supporting cells, smooth muscle cells, bone/cartilage cells, and melanocytes. These cells were easily accessible from the hairy skin and could be isolated as a pure population. The document detailed a protocol for preparing EPI-NCSC cultures from mouse whisker follicles, involving the removal and dissection of whisker follicles, followed by the extraction of the bulge region for culture. EPI-NCSC began to emigrate from the bulge explants within 3 to 4 days.
3 citations
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May 2008 in “Journal of Visualized Experiments” The document described the process of isolating and culturing Mouse Epidermal Neural Crest Stem Cells (EPI-NCSC) from the bulge of hair follicles, specifically from whisker follicles of adult mice. EPI-NCSC were identified as multipotent stem cells capable of differentiating into various cell types, such as neurons, nerve supporting cells, smooth muscle cells, bone/cartilage cells, and melanocytes. The protocol involved removing the whisker pad, dissecting the follicles, and isolating the bulge region, from which EPI-NCSC would emigrate after 3 to 4 days in culture.
29 citations
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June 2014 in “Experimental Cell Research”