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Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

research CDK9 Kinase Activation in Association with AFF1-SEC Initiates Epidermal Progenitor Differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: An Approach to Pathogenesis by Evidence from Translational Biology

112 citations, January 2013 in “Experimental dermatology”

Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations, May 2020 in “Frontiers in immunology”

Hidradenitis suppurativa might be a type of autoinflammatory skin disease.

research Hair Curvature: A Natural Dialectic and Review

28 citations, March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society”

The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.

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community Source for Pyrilutamide has disappeared

in Treatment 21 upvotes 1 year ago

Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

community From Nov. 2022 to today. 2.5 oral min/ .5 oral duta/ Nizoral every once and a while

in Progress Pictures 133 upvotes 1 year ago

A user's progress with hair growth using oral minoxidil, oral dutasteride and Nizoral shampoo every once in a while. Replies indicate that the user has seen good results from this treatment, including thickening and darkening of their hair.

community Pyrilutamide update, comparing with ru58841

in Research/Science 27 upvotes 1 year ago

Treatments for hair loss, including Minoxidil, finasteride, and RU58841. The post discusses the potential benefits of Pyrilutamide compared to RU58841 in terms of strength and longevity.

community Ru-58841 or KX-826 (Pyrilutamide)?

in Treatment 12 upvotes 1 year ago

Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

community My Pyrilutamide Experience Photos

in Update 596 upvotes 1 year ago

A user's experience with Pyrilutamide, a topical treatment for hair loss that they used in combination with other treatments such as Minoxidil and Finasteride. The user experienced impressive results in a short amount of time.

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