Melatonin in the Topical Treatment of Androgenetic Alopecia

This review discusses the role of melatonin in skin and hair physiology, highlighting clinical evidence for its potential benefits in treating androgenetic alopecia, but does not report new results.

This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.

This article discusses melatonin's roles in skin and hair growth, highlighting its antioxidative and anti-inflammatory properties, but reports no new clinical results.

This study highlights that topical melatonin formulations have the potential to increase hair density, prolong the hair growth phase, and reduce shedding in adults with alopecia, while generally being safe, though further large-scale randomized trials are needed to confirm its clinical efficacy.

In this clinical study, melatonin treatment reduced oxidative stress markers and enhanced hair growth in patients with alopecia areata, potentially through its effects on the immune system and antioxidant activity.