Formation of the Cornified Envelope

    September 2005 in “ Experimental dermatology ”
    Daniel Hohl
    Image of study
    TLDR The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
    The formation of the cornified envelope (CE) in the epidermis was essential for skin's barrier function, involving the transformation of keratinocytes and the integration of key proteins like involucrin, loricrin, and small proline-rich proteins, cross-linked by transglutaminases (TGs) 1, 3, and 5. Desmosomes and lamellar granules (LGs) played crucial roles in CE formation and barrier maintenance. Mutations in TG1 and TG5 were linked to skin disorders such as lamellar ichthyosis and Peeling Skin Syndrome. The study highlighted the complex interplay of proteins, lipids, and genetic factors in maintaining skin integrity, with significant roles for ceramides, tight junctions, and transcription factors like p63, Klf4, and Nrf2 in epidermal differentiation and response to oxidative stress.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 55 results

      community Certified old, at 51, balding since 25, the resurrection!

      in Progress Pictures  439 upvotes 3 weeks ago
      A 51-year-old shared progress on hair regrowth using topical Minoxidil and Finasteride over four months, noting significant improvement and plans for future hair transplants. The user emphasized the benefits of modern treatments and societal changes in attitudes towards hair loss.

      community I just went to a dermatologist and there were many red flags about him.

      in Treatment  13 upvotes 1 year ago
      A user visited a dermatologist for hair loss concerns and was prescribed a hair lotion called "Lotion revolotion evdermia," which is meant for hair toning, hydration, and anti-aging, not regrowth. The user found the dermatologist's behavior and the prescription to be questionable.

      community Oral Min & Fin - 9 Months no results - diffuse thinner

      in Treatment  6 upvotes 7 months ago
      A 21-year-old has been using 0.4mg finasteride and 1mg oral minoxidil (increased to 2mg) for 9 months with no noticeable hair growth and worsening hair condition. They are considering stopping finasteride due to side effects and are seeking advice on other treatments.

      community I just want to say Ru58841 saved my life.

      in Chat  28 upvotes 1 year ago
      A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

      community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

      in Minoxidil  39 upvotes 5 years ago
      Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

    Similar Research

    5 / 1000+ results