Epidermal Barrier
February 2022
in “
Cosmetic Dermatology
”
TLDR Healthy skin prevents water loss and protects against threats.
The epidermal barrier, mainly formed by the stratum corneum, prevents water and electrolyte loss and protects against environmental threats. Corneocytes and lipids are crucial for this barrier, with lipids synthesized and secreted by keratinocytes. The epidermis also produces antimicrobial substances. Conditions like atopic dermatitis and psoriasis can compromise this barrier by altering lipid composition and organization. Effective skincare can enhance barrier function and mitigate these issues.
