TLDR Healthy skin prevents water loss and protects against threats.
The epidermal barrier, primarily formed by the stratum corneum, prevents water and electrolyte loss. Corneocytes, derived from keratinocytes, and lipids delivered by lamellar granules, are crucial components. The epidermis also produces antimicrobial substances, contributing to its protective function. Epidermal lipids are synthesized and secreted by keratinocytes in the stratum granulosum. The skin is continuously exposed to a hostile environment.
23 citations
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February 2015 in “The American journal of pathology” Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.
108 citations
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October 2003 in “Journal of biological chemistry/The Journal of biological chemistry” Trichohyalin makes hair follicles stronger.
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January 2018 in “Elsevier eBooks” Lipid nanoparticles improve drug delivery through the skin, offering stability, controlled release, and better compatibility with skin.
21 citations
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March 2018 in “American Journal Of Pathology” Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.
93 citations
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April 2012 in “International Journal of Cosmetic Science” Improving skin barrier and using antifungal treatments can help manage dandruff.
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April 2010 in “The Open Dermatology Journal” Corneodesmosin is essential for skin and hair health, and its dysfunction can lead to skin and hair disorders.
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January 2013 Glucosylceramides are essential for healthy skin and proper wound healing.
