Epidermal Barrier

February 2022 in “ Cosmetic Dermatology ”

Sreekumar Pillai, Megan Manco, Christian Oresajo, Nada Baalbaki

epidermal barrier stratum corneum corneocytes lipids keratinocytes antimicrobial substances atopic dermatitis psoriasis lipid composition skincare skin barrier skin cells skin lipids skin care

TLDR Healthy skin prevents water loss and protects against threats.

The epidermal barrier, primarily formed by the stratum corneum, prevents water and electrolyte loss. Corneocytes, derived from keratinocytes, and lipids delivered by lamellar granules, are crucial components. The epidermis also produces antimicrobial substances, contributing to its protective function. Epidermal lipids are synthesized and secreted by keratinocytes in the stratum granulosum. The skin is continuously exposed to a hostile environment.

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