Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

November 2018 in “ Cell reports ”

SungKyoung Lee, Benjamin Cieply, Youshan Yang, Natoya Peart, Carl Glaser, Patricia P. Chan, Russ P. Carstens

Esrp1 Esrp2 epithelial tight junctions Rho GTP exchange factor Arhgef11 RhoA myosin light chain MLC CRISPR/Cas9 splicing regulators CRISPR

Studysummary This study found that the ablation of Esrp1 and Esrp2 disrupts epithelial tight junctions by affecting Arhgef11 isoform expressions, highlighting a potential mechanistic link between splicing alterations and epithelial barrier defects.

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