Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

    November 2018 in “ Cell reports ”
    SungKyoung Lee, Benjamin Cieply, Youshan Yang … Russ P. Carstens
    Studysummary This study found that the ablation of Esrp1 and Esrp2 disrupts epithelial tight junctions by affecting Arhgef11 isoform expressions, highlighting a potential mechanistic link between splicing alterations and epithelial barrier defects.
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    Research cited in this study 3

    1. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014
    2. Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine · 2013
    3. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000