Improvement in Physicochemical Parameters of DPPC Liposomes and Increase in Skin Permeation of Aciclovir and Minoxidil by the Addition of Cationic Polymers

    June 2010 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Amra Hasanovic, Caroline Hollick, Kerstin Fischinger, Claudia Valenta
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    TLDR Cationic polymers improved liposome stability and increased skin absorption of aciclovir and minoxidil.
    This study from 12 years ago investigated the use of cationic polymers to improve the physicochemical stability of DPPC liposomes and increase skin permeation of aciclovir and minoxidil. The addition of chitosan and Eudragit EPO-coated liposomes increased skin permeation efficiency, possibly due to the positively charged liposomes interacting stronger with the skin surface or the polymers interacting with skin lipids and disrupting tight junctions in lower epidermis layers. The study found that the addition of EU improved the skin permeation of minoxidil.
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