Skin Permeation of Different Steroid Hormones from Polymeric Coated Liposomal Formulations

    October 2005 in “ European journal of pharmaceutics and biopharmaceutics ”
    Babette Biruss, Claudia Valenta
    TLDR Polymers increased skin permeation and stability of steroid hormones in liposomal formulations.
    In this study, researchers investigated the effect of various polymers (polycarbophil, chitosan–EDTA, polymeric emulsifier, and carrageenan) on the permeation, chemical, and microbial stability of 17-β-estradiol, progesterone, cyproterone acetate (CPA), and finasteride incorporated in DPPC liposomes. The liposomes contained 1% (w/w) of the steroid hormones, and standard diffusion experiments were performed over 8 weeks. Results showed that the addition of polymeric agents improved the permeation rate and significantly enhanced both the chemical and microbial stability of the hormones compared to pure liposomes. Finasteride exhibited the highest diffusion among the tested formulations. The study concluded that polymers could form a stable layer around the vesicles, improving the stability and viscosity of the liposomal preparations.
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