Role of FGFR2-Signaling in the Pathogenesis of Acne

    May 2009 in “ Dermato-endocrinology ”
    Bodo C. Melnik
    TLDR Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
    The document explored the role of FGFR2-signaling in the pathogenesis of acne, indicating that mutations in the FGFR2 gene were linked to abnormal sebaceous gland activity and increased androgen sensitivity, contributing to acne development. It suggested that targeting FGFR2 pathways could offer new therapeutic approaches for managing acne, providing insights into the molecular mechanisms underlying the condition.
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