Role of FGFR2-Signaling in the Pathogenesis of Acne

May 2009 in “ Dermato-endocrinology ”

Bodo C. Melnik

FGFR2-signaling FGFR2 gene sebaceous gland androgen sensitivity acne pathogenesis therapeutic approaches molecular mechanisms FGFR2 treatment

TLDR Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

The document explored the role of FGFR2-signaling in the pathogenesis of acne, indicating that mutations in the FGFR2 gene were linked to abnormal sebaceous gland activity and increased androgen sensitivity, contributing to acne development. It suggested that targeting FGFR2 pathways could offer new therapeutic approaches for managing acne, providing insights into the molecular mechanisms underlying the condition.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research The Role of Fibroblast Growth Factor Receptor 2b in Skin Homeostasis and Cancer Development

125 citations , February 2007 in “The EMBO Journal”

Fgfr2b helps maintain healthy skin and prevent cancer.

research Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

226 citations , August 2006 in “Molecular and Cellular Biology”

EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

90 citations , February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Interleukin-1 increases keratin K6 production in skin cells.

research Nevus Comedonicus

44 citations , January 1999 in “Dermatology”

Nevus comedonicus is a rare skin condition with grouped open pores, sometimes linked to other body issues.

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.